Ammonium persulfate can initiate an asthmatic response in mice

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Ammonium persulfate can initiate an asthmatic response in mice.

BACKGROUND Persulfate salts are the main cause of occupational asthma (OA) in hairdressers. The aim of this study was to verify whether ammonium persulfate ((NH(4))(2)S(2)O(8), AP) is capable of triggering an asthma-like response in mice. METHODS BALB/c mice were dermally treated on days 1 and 8, with dimethylsulfoxide (DMSO), 1% AP or 5% AP (20 microl/ear). On day 15, the auricular lymph nod...

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Persistence of Asthmatic Response after Ammonium Persulfate-Induced Occupational Asthma in Mice

INTRODUCTION Since persulfate salts are an important cause of occupational asthma (OA), we aimed to study the persistence of respiratory symptoms after a single exposure to ammonium persulfate (AP) in AP-sensitized mice. MATERIAL AND METHODS BALB/c mice received dermal applications of AP or dimethylsulfoxide (DMSO) on days 1 and 8. On day 15, they received a single nasal instillation of AP or...

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ژورنال

عنوان ژورنال: Thorax

سال: 2010

ISSN: 0040-6376

DOI: 10.1136/thx.2009.121293